Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system

Porhyromonas gingivalis, a causative bacterium of periodontitis, is implicated in the etiology of rheumatoid arthritis (RA), mainly because of expressing peptidyl arginine deiminase (PAD) that generates RA-related autoantigens. However, compared with other periodontopathic bacteria, the precise role...

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Udgivet i:Sci Rep
Main Authors: Sato, Keisuke, Takahashi, Naoki, Kato, Tamotsu, Matsuda, Yumi, Yokoji, Mai, Yamada, Miki, Nakajima, Takako, Kondo, Naoki, Endo, Naoto, Yamamoto, Reiko, Noiri, Yuichiro, Ohno, Hiroshi, Yamazaki, Kazuhisa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537233/
https://ncbi.nlm.nih.gov/pubmed/28761156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07196-7
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