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Cell cycle regulated interaction between Mcm10 and double hexameric Mcm2-7 is required for helicase splitting and activation during S phase
Mcm2-7 helicase is loaded onto double stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling to trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular frac...
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| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5536962/ https://ncbi.nlm.nih.gov/pubmed/26686640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.018 |
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