Cell cycle regulated interaction between Mcm10 and double hexameric Mcm2-7 is required for helicase splitting and activation during S phase

Mcm2-7 helicase is loaded onto double stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling to trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular frac...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Quan, Yun, Xia, Yisui, Liu, Lu, Cui, Jiamin, Li, Zhen, Cao, Qinhong, Chen, Xiaojiang S., Campbell, Judith L, Lou, Huiqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536962/
https://ncbi.nlm.nih.gov/pubmed/26686640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.018
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