Rational Design of Recombinant Papain-Like Cysteine Protease: Optimal Domain Structure and Expression Conditions for Wheat-Derived Enzyme Triticain-α

Triticain-α is a papain-like cysteine protease from wheat (Triticum aestivum L.) that possesses activity towards toxic gluten-derived peptides, and was thus proposed as a novel therapeutic tool for celiac disease. We report an original approach employing rational design of domain architecture of Tri...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Gorokhovets, Neonila V., Makarov, Vladimir A., Petushkova, Anastasiia I., Prokopets, Olga S., Rubtsov, Mikhail A., Savvateeva, Lyudmila V., Zernii, Evgeni Yu., Zamyatnin, Andrey A.
Format: Artigo
Language:Inglês
Published: MDPI 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535888/
https://ncbi.nlm.nih.gov/pubmed/28661426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18071395
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