Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

BACKGROUND: Germline mutations in BRCA1/2 and ATM have been associated with prostate cancer (PCa) risk. OBJECTIVE: To directly assess whether germline mutations in these three genes distinguish lethal from indolent PCa and whether they confer any effect on age at death. DESIGN, SETTING, AND PARTICIP...

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Pubblicato in:Eur Urol
Autori principali: Na, Rong, Zheng, S. Lilly, Han, Misop, Yu, Hongjie, Jiang, Deke, Shah, Sameep, Ewing, Charles M., Zhang, Liti, Novakovic, Kristian, Petkewicz, Jacqueline, Gulukota, Kamalakar, Helseth, Donald L., Quinn, Margo, Humphries, Elizabeth, Wiley, Kathleen E., Isaacs, Sarah D., Wu, Yishuo, Liu, Xu, Zhang, Ning, Wang, Chi-Hsiung, Khandekar, Janardan, Hulick, Peter J., Shevrin, Daniel H., Cooney, Kathleen A., Shen, Zhoujun, Partin, Alan W., Carter, H. Ballentine, Carducci, Michael A., Eisenberger, Mario A., Denmeade, Sam R., McGuire, Michael, Walsh, Patrick C., Helfand, Brian T., Brendler, Charles B., Ding, Qiang, Xu, Jianfeng, Isaacs, William B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535082/
https://ncbi.nlm.nih.gov/pubmed/27989354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2016.11.033
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