Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

BACKGROUND: Germline mutations in BRCA1/2 and ATM have been associated with prostate cancer (PCa) risk. OBJECTIVE: To directly assess whether germline mutations in these three genes distinguish lethal from indolent PCa and whether they confer any effect on age at death. DESIGN, SETTING, AND PARTICIP...

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Publicado no:Eur Urol
Main Authors: Na, Rong, Zheng, S. Lilly, Han, Misop, Yu, Hongjie, Jiang, Deke, Shah, Sameep, Ewing, Charles M., Zhang, Liti, Novakovic, Kristian, Petkewicz, Jacqueline, Gulukota, Kamalakar, Helseth, Donald L., Quinn, Margo, Humphries, Elizabeth, Wiley, Kathleen E., Isaacs, Sarah D., Wu, Yishuo, Liu, Xu, Zhang, Ning, Wang, Chi-Hsiung, Khandekar, Janardan, Hulick, Peter J., Shevrin, Daniel H., Cooney, Kathleen A., Shen, Zhoujun, Partin, Alan W., Carter, H. Ballentine, Carducci, Michael A., Eisenberger, Mario A., Denmeade, Sam R., McGuire, Michael, Walsh, Patrick C., Helfand, Brian T., Brendler, Charles B., Ding, Qiang, Xu, Jianfeng, Isaacs, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535082/
https://ncbi.nlm.nih.gov/pubmed/27989354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2016.11.033
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