Germline Mutations in ATM and BRCA1/2 Are Associated with Grade Reclassification in Men on Active Surveillance for Prostate Cancer

BACKGROUND: Mutations in DNA repair genes are associated with aggressive prostate cancer (PCa). OBJECTIVE: To assess whether germline mutations are associated with grade reclassification (GR) in patients undergoing active surveillance (AS). DESIGN, SETTING, AND PARTICIPANTS: Two independent cohorts...

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Gepubliceerd in:Eur Urol
Hoofdauteurs: Carter, H. Ballentine, Helfand, Brian, Mamawala, Mufaddal, Wu, Yishuo, Landis, Patricia, Yu, Hongjie, Wiley, Kathleen, Na, Rong, Shi, Zhuqing, Petkewicz, Jacqueline, Shah, Sameep, Fantus, Richard J., Novakovic, Kristian, Brendler, Charles B., Zheng, S. Lilly, Isaacs, William B., Xu, Jianfeng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699614/
https://ncbi.nlm.nih.gov/pubmed/30309687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2018.09.021
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