Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation

Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters, and retinyl esters (REs). We previously provided evidence for the presence of two disti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tuohetahuntila, Maidina, Molenaar, Martijn R., Spee, Bart, Brouwers, Jos F., Wubbolts, Richard, Houweling, Martin, Yan, Cong, Du, Hong, VanderVen, Brian C., Vaandrager, Arie B., Helms, J. Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535019/
https://ncbi.nlm.nih.gov/pubmed/28615446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.778472
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