Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions

The activity of tumor necrosis factor (TNF), a cytokine involved in inflammatory pathologies, can be inhibited by antibodies or trap molecules. Herein, llama-derived variable heavy-chain domains of heavy-chain antibody (VHH, also called Nanobodies™) were generated for the engineering of bivalent con...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Beirnaert, Els, Desmyter, Aline, Spinelli, Silvia, Lauwereys, Marc, Aarden, Lucien, Dreier, Torsten, Loris, Remy, Silence, Karen, Pollet, Caroline, Cambillau, Christian, de Haard, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534440/
https://ncbi.nlm.nih.gov/pubmed/28824615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00867
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