Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

Degradation of Gram-positive bacterial cell wall peptidoglycan in macrophage and dendritic cell phagosomes leads to activation of the NLRP3 inflammasome, a cytosolic complex that regulates processing and secretion of interleukin (IL)-1β and IL-18. While many inflammatory responses to peptidoglycan a...

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Vydáno v:Cell
Hlavní autoři: Wolf, Andrea J., Reyes, Christopher N., Liang, Wenbin, Becker, Courtney, Shimada, Kenichi, Wheeler, Matthew L., Cho, Hee Cheol, Popescu, Narcis I., Coggeshall, K. Mark, Arditi, Moshe, Underhill, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534359/
https://ncbi.nlm.nih.gov/pubmed/27374331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.076
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