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Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N(6)-Adenosine Methylation To Promote Lytic Replication

N(6)-adenosine methylation (m(6)A) is the most common posttranscriptional RNA modification in mammalian cells. We found that most transcripts encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome undergo m(6)A modification. The levels of m(6)A-modified mRNAs increased substantial...

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Publicat a:J Virol
Autors principals: Ye, Fengchun, Chen, E. Ricky, Nilsen, Timothy W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533915/
https://ncbi.nlm.nih.gov/pubmed/28592530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00466-17
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