A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule

A number of autoimmune diseases are associated with the genotypes of human leukocyte antigen class II (HLA), some of which present peptides derived from self-proteins, resulting in clonal expansion of self-reactive T cells. Therefore, selective inhibition of self-peptide loading onto such disease-as...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Watanabe, Nobuo, Suzuki, Yusuke, Yonezu, Takahisa, Nakagawa, Yuki, Shiina, Takashi, Hirayama, Noriaki, Inokuchi, Sadaki, Inoue, Shigeaki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533769/
https://ncbi.nlm.nih.gov/pubmed/28754892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07080-4
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