Protein–DNA charge transport: Redox activation of a DNA repair protein by guanine radical

DNA charge transport (CT) chemistry provides a route to carry out oxidative DNA damage from a distance in a reaction that is sensitive to DNA mismatches and lesions. Here, DNA-mediated CT also leads to oxidation of a DNA-bound base excision repair enzyme, MutY. DNA-bound Ru(III), generated through a...

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Hauptverfasser: Yavin, Eylon, Boal, Amie K., Stemp, Eric D. A., Boon, Elizabeth M., Livingston, Alison L., O'Shea, Valerie L., David, Sheila S., Barton, Jacqueline K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Physical Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC553321/
https://ncbi.nlm.nih.gov/pubmed/15738421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409410102
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