Epigenetic Specificity of Loss of Imprinting of the IGF2 Gene in Wilms Tumors

Loss of imprinting (LOI) of the IGF2 gene (which encodes insulin-like growth factor II) is the most common genetic or epigenetic alteration in Wilms tumor; LOI involves aberrant activation of the normally repressed maternally inherited allele. We found previously that LOI of IGF2 occurs in approxima...

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Publicado en:J Natl Cancer Inst
Autores principales: Bjornsson, Hans T., Brown, Lindsey J., Fallin, M. Danielle, Rongione, Michael A., Bibikova, Marina, Wickham, Eliza, Fan, Jian-Bing, Feinberg, Andrew P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533193/
https://ncbi.nlm.nih.gov/pubmed/17686827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djm069
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