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An activator of an adenylation domain revealed by activity but not sequence homology

Nonribosomal peptide synthetases (NRPSs), responsible for synthesizing many medicinally important natural products, frequently use adenylation domain activators (ADAs) to promote substrate loading. Although ADAs are usually MbtH-like proteins (MLPs), a new type of ADA appears to promote an NRPS-depe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chembiochem
Prif Awduron: Saha, Shalini, Rokita, Steven E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531763/
https://ncbi.nlm.nih.gov/pubmed/27447757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600291
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