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Phospholipase A activity of adenylate cyclase toxin mediates translocation of its adenylate cyclase domain
Adenylate cyclase toxin (ACT or CyaA) plays a crucial role in respiratory tract colonization and virulence of the whooping cough causative bacterium Bordetella pertussis. Secreted as soluble protein, it targets myeloid cells expressing the CD11b/CD18 integrin and on delivery of its N-terminal adenyl...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5565420/ https://ncbi.nlm.nih.gov/pubmed/28760979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701783114 |
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