Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma

BACKGROUND: STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting metastasis and chemotherapy resistance. The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5. ME...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:PLoS One
Κύριοι συγγραφείς: Yu, Peter Y., Gardner, Heather L., Roberts, Ryan, Cam, Hakan, Hariharan, Seethalakshmi, Ren, Ling, LeBlanc, Amy K., Xiao, Hui, Lin, Jiayuh, Guttridge, Denis C., Mo, Xiaokui, Bennett, Chad E., Coss, Christopher C., Ling, Yonghua, Phelps, Mitch A., Houghton, Peter, London, Cheryl A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2017
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531494/
https://ncbi.nlm.nih.gov/pubmed/28750090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181885
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