Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma

BACKGROUND: STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting metastasis and chemotherapy resistance. The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5. ME...

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Bibliographic Details
Published in:PLoS One
Main Authors: Yu, Peter Y., Gardner, Heather L., Roberts, Ryan, Cam, Hakan, Hariharan, Seethalakshmi, Ren, Ling, LeBlanc, Amy K., Xiao, Hui, Lin, Jiayuh, Guttridge, Denis C., Mo, Xiaokui, Bennett, Chad E., Coss, Christopher C., Ling, Yonghua, Phelps, Mitch A., Houghton, Peter, London, Cheryl A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531494/
https://ncbi.nlm.nih.gov/pubmed/28750090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181885
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