Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO–activating protein (FLAP). LT biosynthesis inhibitors are currently under clinical investigation as treatments for respiratory and cardiovascular diseases. Here, we have revealed a sex bias in the efficiency of cl...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Pace, Simona, Pergola, Carlo, Dehm, Friederike, Rossi, Antonietta, Gerstmeier, Jana, Troisi, Fabiana, Pein, Helmut, Schaible, Anja M., Weinigel, Christina, Rummler, Silke, Northoff, Hinnak, Laufer, Stefan, Maier, Thorsten J., Rådmark, Olof, Samuelsson, Bengt, Koeberle, Andreas, Sautebin, Lidia, Werz, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531400/
https://ncbi.nlm.nih.gov/pubmed/28737505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92885
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