ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

5-Lipoxygenase initiates the biosynthesis of leukotrienes, lipid mediators involved in normal host defense and in inflammatory and allergic disorders. Despite an obvious gender bias in leukotriene-related diseases (e.g., asthma), gender aspects have been neglected in studies on leukotrienes and 5-li...

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Bibliographic Details
Main Authors: Pergola, Carlo, Dodt, Gabriele, Rossi, Antonietta, Neunhoeffer, Eva, Lawrenz, Barbara, Northoff, Hinnak, Samuelsson, Bengt, Rådmark, Olof, Sautebin, Lidia, Werz, Oliver
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597692/
https://ncbi.nlm.nih.gov/pubmed/19064924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809120105
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