Hepatic β-arrestin 2 is essential for maintaining euglycemia

An increase in hepatic glucose production (HGP) represents a key feature of type 2 diabetes. This deficiency in metabolic control of glucose production critically depends on enhanced signaling through hepatic glucagon receptors (GCGRs). Here, we have demonstrated that selective inactivation of the G...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Zhu, Lu, Rossi, Mario, Cui, Yinghong, Lee, Regina J., Sakamoto, Wataru, Perry, Nicole A., Urs, Nikhil M., Caron, Marc G., Gurevich, Vsevolod V., Godlewski, Grzegorz, Kunos, George, Chen, Minyong, Chen, Wei, Wess, Jürgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531395/
https://ncbi.nlm.nih.gov/pubmed/28650340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92913
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