Intranasal administration of vitamin D attenuates blood–brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats

In this study, we investigated the role of vitamin D3 (VitD3) on endogenous osteopontin (OPN), a neuroprotective glycoprotein, after subarachnoid hemorrhage (SAH). The endovascular perforation SAH model in Sprague-Dawley rats was used to study the effect of intranasal VitD3 (30 ng/kg) before (Pre-SA...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Enkhjargal, Budbazar, McBride, Devin W, Manaenko, Anatol, Reis, Cesar, Sakai, Yasushi, Tang, Jiping, Zhang, John H
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531351/
https://ncbi.nlm.nih.gov/pubmed/27671249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16671147
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