Intranasal administration of recombinant Netrin-1 attenuates neuronal apoptosis by activating DCC/APPL-1/AKT signaling pathway after subarachnoid hemorrhage in rats

Neuronal apoptosis is a crucial pathological process in early brain injury after subarachnoid hemorrhage (SAH). The effective therapeutic strategies to ameliorate neuronal apoptosis are still absent. We intended to determine whether intranasal administration of exogenous Netrin-1 (NTN-1) could atten...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Xie, Zongyi, Huang, Lei, Enkhjargal, Budbazar, Reis, Cesar, Wan, Weifeng, Tang, Jiping, Cheng, Yuan, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490977/
https://ncbi.nlm.nih.gov/pubmed/28347836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.03.025
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