The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis

Modulation of macrophage polarization and prevention of CCL2-induced macrophage chemotaxis are emerging strategies to reduce wear particle induced osteolysis and aseptic total joint replacement loosening. In this study, the effect of continuous IL-4 delivery or bioactive implant coating that constit...

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Détails bibliographiques
Publié dans:J Biomed Mater Res A
Auteurs principaux: Sato, Taishi, Pajarinen, Jukka, Behn, Anthony, Jiang, Xinyi, Lin, Tzu-hua, Loi, Florence, Yao, Zhenyu, Egashira, Kensuke, Yang, Fan, Goodman, Stuart B.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531282/
https://ncbi.nlm.nih.gov/pubmed/27114284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.35759
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