NKG2D ligand targeted Bispecific T Cell Engagers lead to robust antitumor activity against diverse human tumors

Two new bispecific T cell engaging (BiTE) molecules with specificity for NKG2D ligands were developed and functionally characterized. One, huNKG2D-OKT3, was derived from the extracellular portion of the human NKG2D receptor fused to a CD3ε binding single-chain variable fragment (scFv), known as OKT3...

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Publicado en:Mol Cancer Ther
Autores principales: Godbersen, Claire, Coupet, Tiffany A., Huehls, Amelia M., Zhang, Tong, Battles, Michael B., Fisher, Jan L., Ernstoff, Marc S., Sentman, Charles L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531202/
https://ncbi.nlm.nih.gov/pubmed/28500232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0846
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