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Toxicity induced by a bispecific T cell redirecting protein is mediated by both T cells and myeloid cells in immunocompetent mice()

Bispecific T cell engagers have demonstrated clinical efficacy, however, their use can be accompanied by severe toxicity. Mechanistic understanding of these toxicities is limited by a lack of suitable immunocompetent pre-clinical models. Here, we describe an immunocompetent mouse tumor model which e...

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Detalles Bibliográficos
Publicado en:J Immunol
Main Authors: Godbersen-Palmer, Claire, Coupet, Tiffany A., Grada, Zakaria, Zhang, Samuel C., Sentman, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304495/
https://ncbi.nlm.nih.gov/pubmed/32295875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901401
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