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Toxicity induced by a bispecific T cell redirecting protein is mediated by both T cells and myeloid cells in immunocompetent mice()
Bispecific T cell engagers have demonstrated clinical efficacy, however, their use can be accompanied by severe toxicity. Mechanistic understanding of these toxicities is limited by a lack of suitable immunocompetent pre-clinical models. Here, we describe an immunocompetent mouse tumor model which e...
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| 發表在: | J Immunol |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7304495/ https://ncbi.nlm.nih.gov/pubmed/32295875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901401 |
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