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Sphingomyelin encrypts tissue factor: ATP-induced activation of A-SMase leads to tissue factor decryption and microvesicle shedding

A majority of tissue factor (TF) on cell surfaces exists in an encrypted state with minimal to no procoagulant activity. At present, it is unclear whether limited availability of phosphatidylserine (PS) and/or a specific membrane lipid in the outer leaflet of the plasma membrane contributes to TF en...

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Foilsithe in:Blood Adv
Main Authors: Wang, Jue, Pendurthi, Usha R., Rao, L. Vijaya Mohan
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531194/
https://ncbi.nlm.nih.gov/pubmed/28758160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016003947
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