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The lipid peroxidation product 4-hydroxy-2-nonenal induces tissue factor decryption via ROS generation and the thioredoxin system

Many pathophysiologic agents transform cryptic tissue factor (TF) on cells to prothrombotic TF, and one such stimulus is 4-hydroxy-2-nonenal (HNE), the most abundant aldehyde produced by the oxidation of ω-6 polyunsaturated fatty acids. HNE was shown to induce reactive oxygen species (ROS) generatio...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Ansari, Shabbir A., Pendurthi, Usha R., Rao, L. Vijaya Mohan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729625/
https://ncbi.nlm.nih.gov/pubmed/29296890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010132
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