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Simulating the Fidelity And The Three Mg Mechanism of Pol η and clarifying the validity of transition state theory in enzyme catalysis
Pol η belongs to the important Y family of DNA polymerases that can catalyze translesion synthesis across sites of damaged DNA. This activity involves the reduced fidelity of Pol η for 8-oxo-7,8-dhyedro-2′-deoxoguanosin(8-oxoG). The fundamental interest in Pol η has grown recently with the demonstra...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Proteins |
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| Κύριοι συγγραφείς: | , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5531179/ https://ncbi.nlm.nih.gov/pubmed/28383109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25305 |
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