LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels

Autosomal dominant epilepsy with auditory features results from mutations in leucine-rich glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons. Animal models of LGI1 depletion display spontaneous seizures, however, the function of LGI1 and the mechanisms by which deficiency leads...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Seagar, Michael, Russier, Michael, Caillard, Olivier, Maulet, Yves, Fronzaroli-Molinieres, Laure, De San Feliciano, Marina, Boumedine-Guignon, Norah, Rodriguez, Léa, Zbili, Mickael, Usseglio, Fabrice, Formisano-Tréziny, Christine, Youssouf, Fahamoe, Sangiardi, Marion, Boillot, Morgane, Baulac, Stéphanie, Benitez, María José, Garrido, Juan-José, Debanne, Dominique, El Far, Oussama
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530646/
https://ncbi.nlm.nih.gov/pubmed/28673977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618656114
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