Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B

Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor components: a polysialoganglioside, predominantly GT1b, and synaptotagmin 1/2. It is widely thought that BoNT/B initially binds to GT1b then diffuses in the plane of the membrane to interact with synaptotagmin....

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Flores, Alessandra, Ramirez-Franco, Jorge, Desplantes, Richard, Debreux, Kévin, Ferracci, Géraldine, Wernert, Florian, Blanchard, Marie-Pierre, Maulet, Yves, Youssouf, Fahamoe, Sangiardi, Marion, Iborra, Cécile, Popoff, Michel Robert, Seagar, Michael, Fantini, Jacques, Lévêque, Christian, El Far, Oussama
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731659/
https://ncbi.nlm.nih.gov/pubmed/31431523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908051116
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