Prolonged Expression of an Anti-HIV-1 gp120 Minibody to the Female Rhesus Macaque Lower Genital Tract by AAV Gene Transfer

Topical microbicides are a leading strategy for prevention of HIV mucosal infection to women, however, numerous pharmacokinetic limitations associated with coitally-related dosing strategy have contributed to their limited success. Here we test the hypothesis that adeno-associated virus (AAV) mediat...

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Détails bibliographiques
Publié dans:Gene Ther
Auteurs principaux: Abdel-Motal, Ussama M., Harbison, Carole, Han, Thomas, Pudney, Jeffrey, Anderson, Deborah J., Zhu, Quan, Westmoreland, Susan, Marasco, Wayne A.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530589/
https://ncbi.nlm.nih.gov/pubmed/24965083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.56
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