Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease

Dysregulation of skeletal remodeling is a component of renal osteodystrophy. Previously, we showed that activin receptor signaling is differentially affected in various tissues in chronic kidney disease (CKD). We tested whether a ligand trap for the activin receptor type 2A (RAP-011) is an effective...

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Pubblicato in:Kidney Int
Autori principali: Sugatani, Toshifumi, Agapova, Olga A., Fang, Yifu, Berman, Alycia G., Wallace, Joseph M., Malluche, Hartmut H., Faugere, Marie-Claude, Smith, William, Sung, Victoria, Hruska, Keith A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530394/
https://ncbi.nlm.nih.gov/pubmed/27666759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2016.07.039
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