Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis

OBJECTIVE: Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was to examine the effect of clinically relevant endophenotyping according to sit...

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Detalles Bibliográficos
Publicado en:Ann Rheum Dis
Main Authors: Panoutsopoulou, Kalliope, Thiagarajah, Shankar, Zengini, Eleni, Day-Williams, Aaron G, Ramos, Yolande FM, Meessen, Jennifer MTA, Huetink, Kasper, Nelissen, Rob GHH, Southam, Lorraine, Rayner, N William, Doherty, Michael, Meulenbelt, Ingrid, Zeggini, Eleftheria, Wilkinson, J Mark
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2017
Assuntos:
Clinical and Epidemiological Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530347/
https://ncbi.nlm.nih.gov/pubmed/27974301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2016-210373
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