The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

Long noncoding RNAs (lncRNAs) play important roles in various biological processes such as proliferation, cell death and differentiation. Here, we show that a liver-enriched lncRNA, named liver fibrosis-associated lncRNA1 (lnc-LFAR1), promotes liver fibrosis. We demonstrate that lnc-LFAR1 silencing...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Kun, Han, Xiaohui, Zhang, Zhen, Zheng, Lina, Hu, Zhimei, Yao, Qingbin, Cui, Hongmei, Shu, Guiming, Si, Maojie, Li, Chan, Shi, Zhemin, Chen, Ting, Han, Yawei, Chang, Yanan, Yao, Zhi, Han, Tao, Hong, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529527/
https://ncbi.nlm.nih.gov/pubmed/28747678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00204-4
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