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Targeting the PGD(2)/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives

Prostaglandin D(2) (PGD(2)) released by degranulating mast cells is believed to play a key role in orchestrating mechanisms of inflammation in allergies and asthma. The biological effects of PGD(2) are mediated by D-prostanoid (DP1), CRTH2 (DP2), and thromboxane prostanoid (TP) receptors. The CRTH2...

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Bibliografische gegevens
Gepubliceerd in:Drugs
Hoofdauteurs: Kupczyk, Maciej, Kuna, Piotr
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529497/
https://ncbi.nlm.nih.gov/pubmed/28612233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40265-017-0777-2
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