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Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry

Both function and dysfunction of serine protease inhibitors (serpins) involve massive conformational change in their tertiary structure but the dynamics facilitating these events remain poorly understood. We have studied the dynamic preludes to conformational change in the serpin plasminogen activat...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Petersen, Michael, Madsen, Jeppe B., Jørgensen, Thomas J. D., Trelle, Morten B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529462/
https://ncbi.nlm.nih.gov/pubmed/28747729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06290-0
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