Wird geladen...

Conformational preludes to the latency transition in PAI-1 as determined by atomistic computer simulations and hydrogen/deuterium-exchange mass spectrometry

Both function and dysfunction of serine protease inhibitors (serpins) involve massive conformational change in their tertiary structure but the dynamics facilitating these events remain poorly understood. We have studied the dynamic preludes to conformational change in the serpin plasminogen activat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Petersen, Michael, Madsen, Jeppe B., Jørgensen, Thomas J. D., Trelle, Morten B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529462/
https://ncbi.nlm.nih.gov/pubmed/28747729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06290-0
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!