An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin α(L)β(2)

Within the Ig superfamily (IgSF), intercellular adhesion molecules (ICAMs) form a subfamily that binds the leukocyte integrin α(L)β(2). We report a 1.65-Å-resolution crystal structure of the ICAM-3 N-terminal domain (D1) in complex with the inserted domain, the ligand-binding domain of α(L)β(2). Thi...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Song, Gang, Yang, Yuting, Liu, Jin-huan, Casasnovas, Jose M., Shimaoka, Motomu, Springer, Timothy A., Wang, Jia-huai
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC552929/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15728350/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0500200102
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