Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

The structure of the I domain of integrin αLβ 2 bound to the Ig superfamily ligand ICAM-1 reveals the open ligand binding conformation and the first example of an integrin-IgSF interface. The I domain Mg(2+) directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain residue Glu-241 enab...

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Publicat a:Cell
Autors principals: Shimaoka, Motomu, Xiao, Tsan, Liu, Jin-Huan, Yang, Yuting, Dong, Yicheng, Jun, Chang-Duk, McCormack, Alison, Zhang, Rongguang, Joachimiak, Andrzej, Takagi, Junichi, Wang, Jia-Huai, Springer, Timothy A.
Format: Artigo
Idioma:Inglês
Publicat: 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372089/
https://ncbi.nlm.nih.gov/pubmed/12526797
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