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Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization
Caveolin-1 is a target for academic and pharmaceutical research due to its many cellular roles and associated diseases. We report peptide WL47 (1), a small, high-affinity, selective disrupter of cavolin-1 oligomers. Developed and optimized though screening and analysis of synthetic peptide libraries...
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| Udgivet i: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5529100/ https://ncbi.nlm.nih.gov/pubmed/27010220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01536 |
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