Llwytho...

Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization

Caveolin-1 is a target for academic and pharmaceutical research due to its many cellular roles and associated diseases. We report peptide WL47 (1), a small, high-affinity, selective disrupter of cavolin-1 oligomers. Developed and optimized though screening and analysis of synthetic peptide libraries...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Gilliam, Amanda J. H., Smith, Joshua N., Flather, Dylan, Johnston, Kevin M., Gansmiller, Andrew M., Fishman, Dmitry A., Edgar, Joshua M., Balk, Mark, Majumdar, Sudipta, Weiss, Gregory A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529100/
https://ncbi.nlm.nih.gov/pubmed/27010220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01536
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