A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity

Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein implicated in synucleopathies) aggregates in yeast and mammal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Autophagy
Prif Awduron: Suresh, S. N., Chavalmane, Aravinda K., DJ, Vidyadhara, Yarreiphang, Haorei, Rai, Shashank, Paul, Abhik, Clement, James P., Alladi, Phalguni Anand, Manjithaya, Ravi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2017
Pynciau:
Translational Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529071/
https://ncbi.nlm.nih.gov/pubmed/28350199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1302045
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