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Probing site-specific conformational distributions in protein folding with solid-state NMR
We demonstrate an experimental approach to structural studies of unfolded and partially folded proteins in which conformational distributions are probed at a site-specific level by 2D solid-state (13)C NMR spectroscopy of glassy frozen solutions. Experiments on chemical denaturation of the 35-residu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC552907/ https://ncbi.nlm.nih.gov/pubmed/15718283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406130102 |
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