Host microbiota constantly control maturation and function of microglia in the CNS

As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. We observed substantial contributions of the host microbiota to microglia homeostasis, as germ-free...

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Publicado en:Nat Neurosci
Autores principales: Erny, Daniel, de Angelis, Anna Lena Hrabě, Jaitin, Diego, Wieghofer, Peter, Staszewski, Ori, David, Eyal, Keren-Shaul, Hadas, Mahlakoiv, Tanel, Jakobshagen, Kristin, Buch, Thorsten, Schwierzeck, Vera, Utermöhlen, Olaf, Chun, Eunyoung, Garrett, Wendy S, McCoy, Kathy D, Diefenbach, Andreas, Staeheli, Peter, Stecher, Bärbel, Amit, Ido, Prinz, Marco
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528863/
https://ncbi.nlm.nih.gov/pubmed/26030851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4030
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