Host microbiota constantly control maturation and function of microglia in the CNS

As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. We observed substantial contributions of the host microbiota to microglia homeostasis, as germ-free...

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Bibliografiska uppgifter
I publikationen:Nat Neurosci
Huvudupphovsmän: Erny, Daniel, de Angelis, Anna Lena Hrabě, Jaitin, Diego, Wieghofer, Peter, Staszewski, Ori, David, Eyal, Keren-Shaul, Hadas, Mahlakoiv, Tanel, Jakobshagen, Kristin, Buch, Thorsten, Schwierzeck, Vera, Utermöhlen, Olaf, Chun, Eunyoung, Garrett, Wendy S, McCoy, Kathy D, Diefenbach, Andreas, Staeheli, Peter, Stecher, Bärbel, Amit, Ido, Prinz, Marco
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528863/
https://ncbi.nlm.nih.gov/pubmed/26030851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4030
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