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Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion
Risk factors indicate the importance of oxidative stress during ovarian carcinogenesis. To tolerate oxidative stress, cells activate the transcription factor Nrf2 (Nfe2l2), the master regulator of antioxidant and cytoprotective genes. Indeed, for most cancers, hyperactivity of Nrf2 is observed, and...
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| Publié dans: | Mol Oncol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528817/ https://ncbi.nlm.nih.gov/pubmed/25841766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.03.003 |
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