Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion

Risk factors indicate the importance of oxidative stress during ovarian carcinogenesis. To tolerate oxidative stress, cells activate the transcription factor Nrf2 (Nfe2l2), the master regulator of antioxidant and cytoprotective genes. Indeed, for most cancers, hyperactivity of Nrf2 is observed, and...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: van der Wijst, Monique G.P., Huisman, Christian, Mposhi, Archibold, Roelfes, Gerard, Rots, Marianne G.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528817/
https://ncbi.nlm.nih.gov/pubmed/25841766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.03.003
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