BRCA1‐like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

Triple negative (TN) breast cancers make up some 15% of all breast cancers. Approximately 10–15% are mutant for the tumor suppressor, BRCA1. BRCA1 is required for homologous recombination‐mediated DNA repair and deficiency results in genomic instability. BRCA1‐mutated tumors have a specific pattern...

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Bibliografiska uppgifter
I publikationen:Mol Oncol
Huvudupphovsmän: Severson, Tesa M., Peeters, Justine, Majewski, Ian, Michaut, Magali, Bosma, Astrid, Schouten, Philip C., Chin, Suet-Feung, Pereira, Bernard, Goldgraben, Mae A., Bismeijer, Tycho, Kluin, Roelof J.C., Muris, Jettie J.F., Jirström, Karin, Kerkhoven, Ron M., Wessels, Lodewyk, Caldas, Carlos, Bernards, René, Simon, Iris M., Linn, Sabine
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2015
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528786/
https://ncbi.nlm.nih.gov/pubmed/26004083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.04.011
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