Concomitant inactivation of the p53‐ and pRB‐ functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo

Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as apoptosis, senescence, or DNA repair. In support of this hypothesis, we have prev...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Knappskog, Stian, Berge, Elisabet O., Chrisanthar, Ranjan, Geisler, Stephanie, Staalesen, Vidar, Leirvaag, Beryl, Yndestad, Synnøve, de Faveri, Elise, Karlsen, Bård O., Wedge, David C., Akslen, Lars A., Lilleng, Peer K., Løkkevik, Erik, Lundgren, Steinar, Østenstad, Bjørn, Risberg, Terje, Mjaaland, Ingvild, Aas, Turid, Lønning, Per E.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528784/
https://ncbi.nlm.nih.gov/pubmed/26004085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.04.008
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