Concomitant inactivation of the p53‐ and pRB‐ functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo

Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as apoptosis, senescence, or DNA repair. In support of this hypothesis, we have prev...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Knappskog, Stian, Berge, Elisabet O., Chrisanthar, Ranjan, Geisler, Stephanie, Staalesen, Vidar, Leirvaag, Beryl, Yndestad, Synnøve, de Faveri, Elise, Karlsen, Bård O., Wedge, David C., Akslen, Lars A., Lilleng, Peer K., Løkkevik, Erik, Lundgren, Steinar, Østenstad, Bjørn, Risberg, Terje, Mjaaland, Ingvild, Aas, Turid, Lønning, Per E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528784/
https://ncbi.nlm.nih.gov/pubmed/26004085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.04.008
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