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Prevention of BMS‐777607‐induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics
Targeted inhibition of MET/RON signaling by tyrosine kinase inhibitor BMS‐777607 for cancer treatment is currently under clinical trials. We have previously shown that BMS‐777607 induces chemoresistance in vitro by causing polyploidy, which hampers therapeutic efficacy. Here, we studied polyploidy‐a...
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| Publicado no: | Mol Oncol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528636/ https://ncbi.nlm.nih.gov/pubmed/24444656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.12.014 |
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