mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma

The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes, mTORC1 and mTORC2, which regulate cell growth, survival, and autophagy. Allosteric inhibitors of mTORC1, such as rapamycin, have been extensively used to study tumor cell growth, proliferation, and autophagy but have s...

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Main Authors: Zhao, Lijing, Teng, Bo, Wen, Lianji, Feng, Qingjie, Wang, Hebin, Li, Na, Wang, Yafang, Liang, Zuowen
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2014
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931586/
https://ncbi.nlm.nih.gov/pubmed/24600487
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