Screening and identification of small molecule inhibitors of ErbB2‐induced invasion

ERBB2 amplification and overexpression are strongly associated with invasive cancer with high recurrence and poor prognosis. Enhanced ErbB2 signaling induces cysteine cathepsin B and L expression leading to their higher proteolytic activity (zFRase activity), which is crucial for the invasion of Erb...

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Dades bibliogràfiques
Publicat a:Mol Oncol
Autors principals: Brix, D.M., Rafn, B., Bundgaard Clemmensen, K., Andersen, S.H., Ambartsumian, N., Jäättelä, M., Kallunki, T.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528609/
https://ncbi.nlm.nih.gov/pubmed/25070180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.07.004
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